| Parameter | Value / Observation | |-----------|----------------------| | | 4‑(3‑chloro‑4‑fluorophenyl)‑6‑(4‑pyridyl)‑7‑[1‑(2‑methoxy‑ethyl)piperidin‑4‑yl]quinazoline | | Molecular weight | 465 Da | | cLogP | 2.9 | | pKa (basic nitrogen) | 7.8 | | Key SAR features | • Hinge‑binding quinazoline core (N1‑H forms H‑bond to Val828 in PI3Kδ) • 4‑chloro‑fluoro phenyl substituent enhances PI3Kδ selectivity • Piperidine side‑chain confers PI3Kγ potency and improves solubility | | Synthetic route | 6‑step convergent synthesis from 2‑amino‑4‑fluorobenzonitrile; final N‑alkylation with (2‑methoxy‑ethyl)‑piperidine (overall yield ≈ 38 %) | | Patent | WO2022/147893 (granted 2023) – claims quinazoline derivatives with dual PI3Kδ/γ activity and methods of use in B‑cell malignancies and inflammatory diseases |
is the product identifier for a Japanese adult video (JAV) released by the studio SONE-026
Please provide more context, and I'll do my best to assist you! SONE-026
| Parameter | Value / Observation | |-----------|----------------------| | | 4‑(3‑chloro‑4‑fluorophenyl)‑6‑(4‑pyridyl)‑7‑[1‑(2‑methoxy‑ethyl)piperidin‑4‑yl]quinazoline | | Molecular weight | 465 Da | | cLogP | 2.9 | | pKa (basic nitrogen) | 7.8 | | Key SAR features | • Hinge‑binding quinazoline core (N1‑H forms H‑bond to Val828 in PI3Kδ) • 4‑chloro‑fluoro phenyl substituent enhances PI3Kδ selectivity • Piperidine side‑chain confers PI3Kγ potency and improves solubility | | Synthetic route | 6‑step convergent synthesis from 2‑amino‑4‑fluorobenzonitrile; final N‑alkylation with (2‑methoxy‑ethyl)‑piperidine (overall yield ≈ 38 %) | | Patent | WO2022/147893 (granted 2023) – claims quinazoline derivatives with dual PI3Kδ/γ activity and methods of use in B‑cell malignancies and inflammatory diseases |
is the product identifier for a Japanese adult video (JAV) released by the studio
Please provide more context, and I'll do my best to assist you!
