Additionally, what is "meyd873"? Is that a topic, a keyword, or a username?
MEYD873 (10 mg) was dissolved in 1 mL of acetone and added dropwise to 10 mL of de‑ionized water under vigorous stirring (500 rpm). The mixture was dialyzed (MWCO = 100 kDa) against water (3 × 6 h) to remove residual solvent, yielding self‑assembled nanoparticles (NPs) by nanoprecipitation.
If "meyd873" refers to a specific type of paper or a method not covered here, could you provide more details?
The therapeutic index of many anticancer agents remains limited by systemic toxicity and suboptimal tumour accumulation. Nanocarriers that respond to intrinsic tumour stimuli—most notably acidic pH (≈ 6.5–6.8) and elevated intracellular glutathione (GSH) concentrations (≈ 10 mM) — have emerged as promising strategies to achieve site‑specific drug release (Wang et al. , 2020; Liu & Cheng, 2021). However, most reported systems are singly responsive, which can lead to premature release in off‑target acidic compartments (e.g., inflamed tissues) or insufficient release in heterogeneous tumour microenvironments.
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