Mythili has worked with several co-stars, and her on-screen chemistry with them has been well-received by audiences. Some of her notable co-stars include:

, an architect and interior designer, on April 28, 2022. The ceremony was an intimate religious event held at the . In January 2023, the couple welcomed their first child, a baby boy named Neil Sambath .

for Best Supporting Actress for her role as Meenakshi in this popular romantic comedy. Matinee (2012):

Throughout her career, Mythili has maintained a professional focus despite facing challenges common in the public eye. In recent years, she has expressed interest in making a significant "comeback" to the Malayalam screen, continuing to engage with her audience through social media and occasional film projects like C/O 56 APO , which received international exhibition.