Juq-016 Best «RECOMMENDED – FULL REVIEW»

A solemn nod passed around the table.

| Property | Value | |----------|-------| | | (2R)-2‑[(4‑fluorophenyl)amino]-N‑[3‑(pyridin‑2‑yl)propyl]‑3‑hydroxy‑4‑methyl‑2‑oxo‑1,3‑oxazolidine‑5‑carboxamide | | Molecular formula | C₂₁H₂₅FN₄O₃ | | Molecular weight | 384.44 Da | | SMILES | C[C@H]1C(=O)N(C(=O)NCCCNc2ccccn2)C(O)C1N(c3ccc(F)cc3)C | | Key functional groups | Oxazolidinone core, secondary amine, fluorophenyl, pyridyl side‑chain, carboxamide | | Physical state | White crystalline solid | | Melting point | 215–218 °C (decomp.) | | Solubility | 12 µg mL⁻¹ (pH 7.4, PBS), 85 µg mL⁻¹ (pH 2.0, 0.1 M HCl) | | LogP (XlogP3‑AA) | 2.9 | | pKa (predicted) | 7.1 (basic amine), 3.8 (carboxamide) | | Stability | Stable to ≥ 90 % after 24 h at 37 °C, pH 7.4; hydrolyzes slowly in alkaline media (pH 9) | | Patents | WO 2025/112345 (Jupiter Therapeutics) – “Oxazolidinone‑based modulators of microglial activity” | JUQ-016

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