| Episode # | Title | Air Date | Key Index Points | | :--- | :--- | :--- | :--- | | S4:E16 | What If... | Apr 4, 2017 | The team enters the Framework (Virtual Reality). | | S4:E17 | Identity and Change | Apr 11, 2017 | The dystopian world where HYDRA won. | | S4:E18 | No Regrets | Apr 18, 2017 | Emotional gut-punch. Fitz’s dark side. | | S4:E19 | All the Madame's Men | Apr 25, 2017 | Resistance vs. HYDRA. | | S4:E20 | Farewell, Cruel World! | May 2, 2017 | Escape attempts. | | S4:E21 | The Return | May 9, 2017 | The villain comes to the real world. | | S4:E22 | World's End | May 16, 2017 | Season finale. The birth of a new villain. |